CF20170638
Post-Doctoral Position in Molecular Dynamics Based Design of Enzyme Inhibitors, Lyon, France
J-7
Post-Doc
Chimie
Auvergne-Rhône-Alpes
Disciplines
Chimie Physique, Chimie Analytique, Chimie Pharmaceutique
Laboratoire
SCIENCES ANALYTIQUES
Institution d'accueil
UNIVERSITE CLAUDE-BERNARD-LYON 1
Autre institution
Ecole Normale Supérieure de Lyon

Description

In a public-private partnership with an innovation company located in Lyon, France, a 18-month post-doctoral position is offered at Institut des Sciences Analytiques (ISA) within the Biomolecular Interactions group INTERACT (http://isa-lyon.fr/?page_id=239 ) to develop protocols of molecular dynamics and metadynamics to help the design of high-affinity protein ligands, including efficient enzyme inhibitors. The group and the company have a long-term experience in the affinity analysis using NMR and the chemical synthesis of protein ligands. We expended recently our equipment with dedicated cluster of CPU’s and 15 GPU’s available on site. The successful candidate will optimally have a strong background in computational physical chemistry or physical biochemistry and interest in innovative medicinal chemistry projects.

Lyon (http://www.onlylyon.com/en/) is situated in France in a very enjoyable location and good living standards, next to Switzerland and Italy, efficiently linked to the capital by TGV in 2h and to more than 140 destinations by air.

The partner company anticipates the opening of start of a new department of state-of-the-art modelling of biomolecular interaction in 2019 where the successful candidates could be involved at this time.

 

All inquiries and applications to :

 

Prof. Jean-Marc Lancelin

Institut des Sciences Analytiques

5, rue de la Doua

F-69100 Villeurbanne

Tel +33 04 37 42 35 46

Email: jean-marc.lancelin@isa-lyon.fr

http://isa-lyon.fr/?profile_cct=jean-marc.lancelin

https://www.researchgate.net/profile/Jean-Marc_Lancelin

https://www.linkedin.com/in/jean-marc-lancelin-199ba11b

Compétences requises

The successful candidate will optimally have a strong background in computational physical chemistry or physical biochemistry and interest in innovative medicinal chemistry projects.

Bibliographie

(1) Troussicot, L.; Guilliere, F.; Limongelli, V.; Walker, O.; Lancelin, J. M. J. Am. Chem. Soc. 2015, 137, 1273. (2) Chow, M. L.; Troussicot, L.; Martin, M.; Doumèche, B.; Guillière, F.; Lancelin, J.-M. Biochemistry 2016, 55, 3469-3480

Mots clés

Molecular dynamics Protein ligand interaction NMR Drug design

Offre financée

Type de financement
Contrat de travail

Dates

Date limite de candidature 30/09/17

Durée18 mois

Date de démarrageDès que possible

Date de création15/02/17

Langues

Niveau de français requisAucun

Niveau d'anglais requisC1 (autonome)

Possibilité de faire sa thèse en anglais

Divers

Frais de scolarité annuels391 € / an

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