Description

This thesis aims to develop a sol-gel manufacturing process for bioglasses, into which drugs will be integrated to combat bacterial infections or to act as anti-inflammatories after surgery, during the implantation of these bone substitutes. The objectives of this research will include studying the release kinetics of various therapeutic molecules (such as gentamicin, ibuprofen, vancomycin, and growth factors) integrated into bioglasses composed of the SiO2-Na2O-CaO-P2O5 system, depending on the glass composition. These bioglasses will be analyzed by NMR to determine their structure, which will allow us to establish a link with the drug release kinetics. Bioactivity tests will also be performed in vitro (using simulated physiological fluid) to evaluate the time required for apatite formation on the drug-enhanced bioglasses. Other parameters will need to be considered, such as the specific surface area and pore size of the doped bioglasses, as well as the composition of the medium, since these will influence the release kinetics of the therapeutic molecules. Cytotoxicity tests to assess cell viability and bacterial proliferation will allow for the study of the biocompatibility of the glasses through bone cell colonization studies and their antibacterial activity, respectively.

Skills required

Training in Chemistry Training in Materials Chemistry Training in Biomaterials Knowledge of sol/gel synthesis methods Knowledge of glasses Knowledge of NMR solid Basic knowledge of biology

Bibliography

New Generation of Glass Materials for Biomedical Applications: Properties, Structure, Bioactivity and Viability, Ahmed Bachar, Assia Mabrouk, Cyrille Albert-Mercier, Claudine Follet, Franck Bouchart, Arnaud Tricoteaux, Stuart Hampshire, Chapter 4, In book: Innovative Materials for Industrial Applications: Synthesis, Characterization and Evaluation, Ed. : Assia Mabrouk, Ahmed Bachar, Seitkhan Azat, Rachid Amrousse, November 2024, Copyright: © 2025, 97-134. DOI:10.4018/979-8-3693-7505-1.ch004.
2- The effect of CuO dopant on the bioactivity, the biocompatibility and the antibacterial properties of bioactive glasses synthetized by the sol-gel method, Halima El Bouami, Assia Mabrouk, Cyrille Mercier, Wafa Mihoubi, Edwige Meurice, Claudine Follet, Nadia Faska, Ahmed Bachar, Journal of Sol-Gel Science and Technology, Volume 111, pages 347–361, (2024). (IF : 2,3) https://doi.org/10.18321/ectj1565
3- Sol-Gel Synthesis of a New Composition of Bioactive Glass, Halima El Bouami, Assia Mabrouk, Cyrille Albert-Mercier, Claudine Follet, Ahmed Bachar, Chapter 8, In book : Innovative Materials for Industrial Applications: Synthesis, Characterization and Evaluation, Ed. : Assia Mabrouk, Ahmed Bachar, Seitkhan Azat, Rachid Amrousse, November 2024, Copyright: © 2025, 225-246. DOI:10.4018/979-8-3693-7505-1.ch008.
4- Mechanical Properties, Structure, Bioactivity and Cytotoxicity of Bioactive Na-Ca-Si-P-O-(N) Glasses, Assia Mabrouk, Ahmed Bachar, Ali Atbir, Claudine Follet, Cyrille Mercier, Arnaud Tricoteaux, Anne Leriche, Stuart Hampshire, Journal of the Mechanical Behavior of Biomedical Materials, 86 (2018) 284-293 (IF: 3,372).
5- Bioactivity and Cytotoxicity of Oxynitride Glasses, Assia Mabrouk, Ahmed Bachar, Claudine Follet, Cyrille Mercier, Ali Atbir, Larbi Boukbir, Abdelkhalek Marrouche, Raddoine Bellajrou, Said Mançour-Billah and Miloud El Hadek, Research& Reviews: Journal of Material Sciences, Volume 5, Issue 2, (2017) 83-90 (IF = 0.57.)
6- Bioactive Oxynitride Glasses: Synthesis, Structure and Properties, Ahmed Bachar, Cyrille Mercier, Arnaud Tricoteaux, Anne Leriche, Claudine Follet, Stuart Hampshire, Journal of the European Ceramic Society, Volume 36, Issue 12 (2016) 2869–2881 (IF = 4.495).
7- Effect of Nitrogen on Properties of Na2O–CaO–SrO–ZnO–SiO2 Glasses, Ahmed Bachar, Cyrille Mercier, Arnaud Tricoteaux, Jean-Christophe Hornez, Anne Leriche, Claudine Follet, Bertrand Revel, Stuart Hampshire, and Mark R. Towler, Journal of American Ceramic Society, Volume 98, Issue 3, 2015, 748–757 (IF = 3.094).
8- Effect of nitrogen and fluorine on the properties and bioactivity in two series of bioglasses, A. Bachar, C. Mercier, A. Tricoteaux, S. Hampshire, A. Leriche, C. Follet, Journal of the Mechanical Behavior of Biomedical Materials, 23, 2013, 133-148 (IF = 3.372).
9- Effects of addition of nitrogen on bioglass properties and structure, A. Bachar, C. Mercier, A. Tricoteaux, A. Leriche, C. Follet, M. Saadi, S. Hampshire, Journal of Non-Crystalline Solids, Vol. 358, Issue 3, 2012, 693–701 (IF = 2.929).
10- Influence of P2O5 content on the structure of SiO2-Na2O-CaO-P2O5 bioglasses by 29Si and 31P MAS-NMR, , C. Mercier, C. Follet-Houttemane, A. Pardini, B. Revel Journal of Non-Crystalline Solids 357 (2011) 3901–3909 (IF=1.5)

Keywords

bioglasses, bioactivity, antibacterial activity , sol-gel, structure, NMR